Peer-reviewed veterinary case report
Dog with primary ciliary dyskinesia, reversed organs, and brain fluid
By Reichler, I M et al.·Published in The Journal of small animal practice·2001·Department of Reproduction·View original on PubMed →
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Original publication title: Primary ciliary dyskinesia with situs inversus totalis, hydrocephalus internus and cardiac malformations in a dog.
- Species:
- dog
Plain-English summary
A nine-month-old golden retriever was brought in because she was having trouble exercising and had a runny nose. After various tests, the vet found she had rhinitis (inflammation of the nasal passages), situs inversus totalis (a condition where her organs are mirrored), and a heart valve problem. Unfortunately, the dog was diagnosed with primary ciliary dyskinesia (PCD), a condition affecting her respiratory system, and due to her poor prognosis, she was euthanized. During the examination after her passing, additional issues like hydrocephalus (fluid buildup in the brain) and a heart condition were discovered.
People also search for: golden retriever exercise intolerance · dog nasal discharge treatment · primary ciliary dyskinesia in dogs
Abstract
A nine-month-old golden retriever bitch was presented with exercise intolerance and recurrent nasal discharge. Based on clinical, radiographic and ultrasonographic examination, a diagnosis of rhinitis, situs inversus totalis and tricuspid valve insufficiency was established. The results of video- and electron microscopy studies of the respiratory epithelium were compatible with primary ciliary dyskinesia (PCD). However, no evidence of a primary ultrastructural defect of the cilia was found. The dog was euthanased because of the poor prognosis. At necropsy, a hydrocephalus internus and a subaortic stenosis were additionally diagnosed. PCD, in combination with situs inversus, has been previously reported in golden retrievers, but without a concomitant hydrocephalus internus. Furthermore, concomitant occurrence of internal cardiac malformation and PCD has not previously been reported in the dog.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/11480901/