Peer-reviewed veterinary case report
Frontal sinus cancer in dogs treated with piroxicam and carboplatin
By de Vos, J et al.·Published in Veterinary and comparative oncology·2012·Veterinary Oncology Referral Centre De Ottenhorst, Netherlands·View original on PubMed →
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Original publication title: Primary frontal sinus squamous cell carcinoma in three dogs treated with piroxicam combined with carboplatin or toceranib.
- Species:
- dog
Plain-English summary
Three dogs with a rare type of cancer called primary frontal sinus squamous cell carcinoma (pFS-SCC) were treated with a combination of piroxicam and either carboplatin or toceranib. The tumors were located in the frontal sinus area and had spread into the orbit or brain cavity, but not the nasal cavity. One dog went into complete remission and lived for nearly a year after starting treatment, while another dog is still alive and cancer-free three years later after receiving multiple treatments. The third dog showed some improvement with a different treatment but was euthanized after a relapse.
People also search for: dog frontal sinus cancer treatment · piroxicam for dog cancer · carboplatin for dogs · dog cancer survival rates
Abstract
In human medicine, primary frontal sinus squamous cell carcinoma (pFS-SCC) is not frequently reported. In veterinary medicine, frontal sinus SCC is exclusively described as an extension of nasal cavity SCC. To our knowledge, this is the first publication concerning canine pFS-SCC, diagnosed using histology or cytology and medical imaging, in three dogs. The tumours extended into the orbit or brain cavity, without nasal involvement. Treatment was initiated with piroxicam-carboplatin. Prolongation of carboplatin delivery with a low dose intensity was performed on dogs with a favourable initial response. Dog 1 achieved a complete remission (CR), but was euthanized 344 days after start of therapy. Dog 2, still alive 3 years after start of therapy and in CR, received 14 carboplatin deliveries. In dog 3, after changing the treatment protocol into piroxicam-toceranib, a significant tumour reduction occurred, but the dog was euthanized after 195 days because of a relapse.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22236048/