Peer-reviewed veterinary case report
Brain tumor causing hydrocephalus in 2-month-old Chihuahua dog
By Zabka, T S et al.·Published in Journal of comparative pathology·2004·Veterinary Medical Teaching Hospital (VMTH), United States·View original on PubMed →
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Original publication title: Primary intra-axial leiomyosarcoma with obstructive hydrocephalus in a young dog.
- Species:
- dog
Plain-English summary
A 2-month-old female Chihuahua was brought in with worsening neurological symptoms, including strange behavior, disorientation, circling to the left, and constant whimpering over the past three weeks. Unfortunately, a necropsy revealed that she had a primary leiomyosarcoma (a type of cancer) in her brain, which caused fluid buildup and pressure (obstructive hydrocephalus). This serious condition can lead to significant health issues in young dogs. Sadly, due to the advanced nature of the disease, treatment options were limited, and the prognosis was poor.
People also search for: puppy neurological signs · Chihuahua brain tumor symptoms · obstructive hydrocephalus in dogs
Abstract
A female Chihuahua dog aged 2 months had a 3-week history of progressive neurological signs (abnormal behaviour, disorientation, left-sided circling, and incessant whimpering). Necropsy revealed a primary leiomyosarcoma in the midline of the posterior thalamus with secondary obstructive hydrocephalus of the lateral ventricles. Grossly, an infiltrative, grey-white tumour had partly invaded the third ventricle. Histologically, the tumour formed hypercellular, interlacing bundles of neoplastic spindle cells with blunt-ended nuclei. Neoplastic cells were strongly immunoreactive for vimentin and both muscle-specific and alpha-smooth muscle actin; MIB-1 immunoreactivity indicated a proliferative index of up to 5%. Leiomyosarcoma should be included in the differential diagnosis for primary brain tumours and hydrocephalus in young dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15511542/