Peer-reviewed veterinary case report
Intranasal perivascular wall tumors found in 2 cats
By Godizzi, Francesco et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2023·Department of Veterinary Medicine and Animal Sciences (DIVAS), Italy·View original on PubMed →
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Original publication title: Primary intranasal perivascular wall tumors in 2 cats.
- Species:
- cat
Plain-English summary
A 5-year-old domestic shorthair cat developed a growth inside its nose that caused breathing difficulties and nasal discharge. The tumor was identified as a type of perivascular wall tumor, which is rare in cats. Unfortunately, the tumor was only partially removed during surgery, leading to a recurrence of symptoms. The second cat with a similar tumor was lost to follow-up, so its outcome is unknown. These cases highlight a new type of nasal tumor in cats that may require more attention from veterinarians.
People also search for: cat nasal tumor symptoms · cat breathing problems · cat surgery for nasal growth · cat tumor recurrence treatment
Abstract
Perivascular wall tumors (PWTs) are common well-known canine mesenchymal tumors. The term PWT has not yet been applied to cats; only 2 cases of feline soft tissue hemangiopericytomas (HEPs) are available. In human medicine, sinonasal HEP-like tumor/glomangiopericytoma (SHPCL/GP) and intranasal solitary fibrous tumor (SFT) are well-known mesenchymal tumors with staghorn vasculature and low malignant potential; however, these entities have not been described in small animals. We describe here the pathologic and immunohistochemical features of 2 cases of feline intranasal mesenchymal tumors consistent with PWTs and resembling human SHPCL/GP (case 1), and human intranasal SFT (case 2). Both cats developed intranasal, unilateral, polypoid, expansile neoplasms with a mostly patternless growth of spindle cells, minimal stroma, and prominent staghorn vessels. The stroma was PAS negative, which excludes a glomus tumor. Immunohistochemistry identified diffuse vimentin and PDGFRβ expression. Case 1 was α-SMA positive (as is human SHPCL/GP); case 2 was negative (as is human intranasal SFT). Both tumors were incompletely excised, leading to recurrence in case 1. Case 2 was lost to follow up. To our knowledge, intranasal PWTs have not been reported previously in cats. The frequency of the lesions is not known, but awareness of these entities may assist in their recognition and better characterization in the future.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36416407/