Peer-reviewed veterinary case report
Surgery outcomes for NSAID-related stomach ulcers in 11 dogs
By Dobberstein, Rachel E A et al.·Published in Veterinary surgery : VS·2022·Department of Clinical Studies, Canada·View original on PubMed →
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Original publication title: Primary repair of nonsteroidal anti-inflammatory drug-associated full thickness gastrointestinal ulcers in 11 dogs.
- Species:
- dog
Plain-English summary
Eleven large breed dogs, averaging about 7 years old, were treated for serious stomach ulcers that had caused perforations, likely due to taking nonsteroidal anti-inflammatory drugs (NSAIDs). Most of these dogs were also given corticosteroids or were on higher doses of NSAIDs than recommended. After surgery to repair the ulcers, 8 out of the 11 dogs recovered and were able to go home. This suggests that surgical repair can be effective for dogs with these types of ulcers, especially when careful monitoring of medication use is practiced.
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Abstract
OBJECTIVE: To report the outcomes of dogs that underwent primary repair of gastroduodenal perforations associated with the administration of nonsteroidal anti-inflammatory drugs (NSAID). A secondary objective was to identify clinicopathological findings that predisposed dogs to postoperative death. STUDY DESIGN: Retrospective study. ANIMALS: Eleven dogs with complete gastric or duodenal perforation related to administration of an NSAID that underwent primary surgical repair. METHODS: Medical records were reviewed for dogs that presented with peritonitis due to a complete gastroduodenal perforation while receiving NSAIDs between November, 2011 and January, 2021. Data collected included patient characteristics, clinical signs, clinicopathological results, surgical details, and postoperative management and outcome. RESULTS: All dogs were large breeds (mean weight 42 kg; range 22-75 kg), with a mean age of 7.35 years. Nine dogs from a total of 11 (82 %) received a concurrent corticosteroid and NSAID, or a higher dose/frequency/length of NSAID administration than recommended by the manufacturer. All gastroduodenal perforations were found in the upper gastrointestinal tract. Eight of 11 (73%) dogs survived to discharge. The median postoperative duration of follow up was 444 days (range 2-1460 days). No association was detected between ulcer size or location and mortality. CONCLUSION: Most dogs who underwent primary repair of complete gastroduodenal ulcers survived. Gastroduodenal perforations were generally due to the administration of higher or longer doses of NSAIDs, or concurrent administration of another NSAID or corticosteroid. CLINICAL SIGNIFICANCE: Primary closure may be associated with a high success rate in dogs with full thickness gastroduodenal ulcers.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35866930/