Peer-reviewed veterinary case report
Dog with splenic nerve sheath tumor causing weakness and belly
By Bergmann, W et al.·Published in Journal of comparative pathology·2009·Institute of Animal Pathology·View original on PubMed →
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Original publication title: Primary splenic peripheral nerve sheath tumour in a dog.
- Species:
- dog
Plain-English summary
An 8-year-old crossbred dog was brought to the vet after showing signs of weakness, trouble breathing, and a swollen belly for about a month. During surgery, the vet found a mass on the spleen that was growing into nearby organs. Tests showed that this mass was a malignant peripheral nerve sheath tumor, which is a rare type of cancer in dogs. Unfortunately, this type of tumor can be aggressive, and the specific treatment and outcome for this dog were not detailed in the study.
People also search for: dog weakness and breathing problems · splenic tumor in dogs · malignant nerve sheath tumor in dogs
Abstract
An 8-year-old crossbred dog was presented with a one-month history of progressive weakness, respiratory impairment and abdominal distension. Surgical exploration revealed the presence of a splenic mass that infiltrated the mesentery and was adherent to the stomach and pancreas. The mass was composed of highly cellular areas of spindle-shaped cells arranged in interlacing bundles, streams, whorls and storiform patterns (Antoni A pattern) and less cellular areas with more loosely arranged spindle to oval cells (Antoni B pattern). The majority of neoplastic cells expressed vimentin, S-100 and glial fibrillary acidic protein (GFAP), but did not express desmin, alpha-smooth muscle actin or factor VIII. These morphological and immunohistochemical findings characterized the lesion as a malignant peripheral nerve sheath tumour (PNST). Primary splenic PNST has not been documented previously in the dog.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19477462/