Peer-reviewed veterinary case report
Small cell kidney cancer in a female golden retriever dog
By Sozmen, M et al.·Published in Journal of comparative pathology·2020·Department of Pathology·View original on PubMed →
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Original publication title: Primary Unilateral Small Cell Neuroendocrine Carcinoma of the Kidney in a Dog.
- Species:
- dog
Plain-English summary
A 7.5-year-old female golden retriever was diagnosed with a rare type of kidney cancer after a mass measuring 15 x 20 x 9 cm was found in her abdomen. The tumor replaced her left kidney and was identified as a small cell neuroendocrine carcinoma, which is unusual in dogs. Unfortunately, the details of treatment and outcome were not provided, but this case highlights the need for further research into this type of cancer in pets. If your dog is showing signs of abdominal pain or unusual behavior, it's important to consult your veterinarian for a thorough examination.
People also search for: dog kidney cancer symptoms · golden retriever abdominal mass · dog cancer treatment options
Abstract
Primary small cell carcinomas are rare in domestic animals. A mass measuring 15 × 20 × 9 cm was detected in the left abdominal cavity of a 7.5-year-old female golden retriever. The cut surface of the excised mass showed a tumour replacing the left kidney. Microscopically, the mass was composed of polymorphic, small basophilic cells with a high nuclear to cytoplasmic ratio and round, oval or short slender fusiform nuclei with condensed or finely granular chromatin, absent or inconspicuous nucleoli, and scant, faintly eosinophilic cytoplasm with poorly defined cytoplasmic borders. Immunohistochemically, most of the neoplastic cells were immunoreactive for thyroid transcription factor 1 and CD56, moderately positive for vimentin and weakly or sparsely labelled for chromogranin A, synaptophysin, Wilms' tumour 1 protein, neuron-specific enolase, pan-cytokeratin (CK) AE1/AE3 and epithelial membrane antigen. The tumour cells were negative for glial fibrillary acidic protein (GFAP), ionized calcium-binding adapter molecule 1, CK7, CK20, CD3, CD45 and CD99. These findings indicated a neuroendocrine origin of the tumour. To the best of author's knowledge, this is the first report of a small cell neuroendocrine carcinoma originating as a primary tumour in the kidney of a dog.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32359638/