Peer-reviewed veterinary case report
DNA and vaccinia virus vaccine protects dogs from Babesia gibsoni
By Fukumoto, Shinya et al.·Published in Vaccine·2007·Graduate School of Medicine, Japan·View original on PubMed →
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Original publication title: Prime-boost immunization with DNA followed by a recombinant vaccinia virus expressing P50 induced protective immunity against Babesia gibsoni infection in dogs.
- Species:
- dog
Plain-English summary
A group of dogs received a special vaccination to help protect them from Babesia gibsoni, a parasite that can cause serious illness. They were given a DNA vaccine followed by a booster shot with a modified virus that helps the immune system recognize the parasite. After this treatment, the dogs showed a strong immune response and were partially protected when exposed to the parasite, experiencing less severe symptoms and a delay in the peak of the infection. This approach may be a promising way to help prevent Babesia gibsoni infections in dogs.
People also search for: dog Babesia gibsoni vaccine · dog vaccination for parasites · Babesia infection symptoms in dogs
Abstract
A heterologous prime-boost immunization regime with priming DNA followed by recombinant vaccinia virus expressing relevant antigens has been shown to induce effective immune responses against several infectious pathogens. In this study, we constructed a recombinant plasmid and vaccinia virus, both of which expressed P50 of Babesia gibsoni, to investigate the immunogenicity and protective efficacy of a heterologous prime-boost immunization against canine babesiosis. The dogs immunized with the prime-boost regime developed a significantly high level of specific antibody against P50 when compared with the control groups, and the antibody level was strongly increased after a booster immunization with a recombinant vaccinia virus. The prime-boost immunization regime induced a specific IgG2 antibody response and IFN-gamma production in dogs. Two weeks after the booster immunization with a recombinant vaccinia virus expressing P50, the dogs were challenged with B. gibsoni patasites. The dogs immunized with the prime-boost regime showed partial protection, manifested as a significantly low level of parasitemia and a 2-day delay of the peak parasitemia. These results indicated that such a heterologous prime-boost immunization approach might be useful against B. gibsoni infection in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17055131/