Peer-reviewed veterinary case report
Vaccination with DNA and virus cuts Babesia gibsoni growth in dogs
By Cao, Shinuo et al.·Published in Acta parasitologica·2013·Obihiro University of Agriculture and Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Prime-boost vaccination with plasmid DNA followed by recombinant vaccinia virus expressing BgGARP induced a partial protective immunity to inhibit Babesia gibsoni proliferation in dogs.
- Species:
- dog
Plain-English summary
A group of dogs received a special vaccination to help protect them from Babesia gibsoni, a parasite that can cause serious illness. They were first given a DNA vaccine and then a booster shot with a modified virus that helps the body recognize the parasite. After the booster, these dogs showed a strong immune response and had lower levels of the parasite when exposed to it compared to those who didn't receive the vaccination. This suggests that this vaccination approach could be beneficial in preventing Babesia gibsoni infections in dogs.
People also search for: dog Babesia gibsoni vaccine · dog vaccination for parasites · Babesia gibsoni symptoms in dogs
Abstract
A heterologous prime-boost vaccination regime with DNA and recombinant vaccinia virus (rvv) vectors expressing relevant antigens has been shown to induce effective immune responses against several infectious pathogens. In this study, we describe the effectiveness of the prime-boost strategy by immunizing dogs with a recombinant plasmid followed by vaccinia virus, both of which expressed the glutamic acid-rich protein (BgGARP) of Babesia gibsoni. The dogs immunized with the prime-boost regime developed a significantly high level of specific antibodies against BgGARP when compared with the control groups. The antibody level was strongly increased after a booster immunization with a recombinant vaccinia virus. Two weeks after the booster immunization with a recombinant vaccinia virus expressing BgGARP, the dogs were challenged with B. gibsoni parasite. The dogs immunized with the prime-boost regime showed partial protection, manifested as a significantly low level of parasitemia. These results indicated that this type of DNA/rvv prime-boost immunization approach may have use against B. gibsoni infection in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24338330/