Peer-reviewed veterinary case report
Dog developed skin ulcers and pad sloughing after taking CBD hemp oil
By Simpson, Andrew C et al.·Published in Veterinary dermatology·2020·VCA Aurora Animal Hospital, United States·View original on PubMed →
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Original publication title: Probable cutaneous adverse drug reaction due to a cannabidiol-containing hemp oil product in a dog.
- Species:
- dog
Plain-English summary
A 4-year-old male Labrador retriever developed severe skin and mouth sores just five days after starting an oral CBD oil product. The dog's symptoms included sloughing of the pads and rapidly worsening ulcers, which were diagnosed as a probable adverse reaction to the hemp oil. After stopping the CBD oil and treating with antibiotics and steroids, the dog's skin lesions completely healed. This case highlights the potential for serious skin reactions to CBD products in dogs.
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Abstract
BACKGROUND: Cannabidiol (CBD) in hemp oil has become a widely used product in veterinary medicine. To date, there have been no reports of cutaneous adverse events associated with CBD-containing oil in the veterinary literature. CLINICAL SUMMARY: A 4-year-old castrated male Labrador retriever presented with pad sloughing and rapidly progressive cutaneous and mucosal ulceration within five days of administering an oral CBD oil product. Histopathological findings in combination with cutaneous signs were consistent with Stevens-Johnson syndrome. All lesions completely resolved after discontinuation of the hemp oil in addition to a 12 day course of cephalexin and prednisone. Given the lack of alternative causes including other medications, an adverse drug event was deemed probable according to the Naranjo algorithm. CONCLUSIONS AND CLINICAL IMPORTANCE: To the best of the authors' knowledge, this is the first report of suspected cutaneous adverse drug reaction to a CBD-containing hemp oil product.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32735064/