Peer-reviewed veterinary case report
Dog develops skin allergy to carboplatin chemotherapy treatment
By Lanore, D & Sayag, D·Published in The Journal of small animal practice·2010·Clinique Vé, France·View original on PubMed →
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Original publication title: Probable cutaneous hypersensitivity to carboplatin single-agent chemotherapy in a dog.
- Species:
- dog
Plain-English summary
A 7-year-old mixed-breed dog developed skin problems after receiving carboplatin, a chemotherapy drug typically well-tolerated in dogs. The dog experienced a delayed hypersensitivity reaction, which was confirmed through skin testing. To manage this, the veterinarian treated the dog with antihistamines and adjusted future carboplatin doses by giving corticosteroids beforehand and reducing the initial dose by 20%. After these changes, the dog did not have any further reactions during subsequent treatments.
People also search for: dog skin problems after chemotherapy · carboplatin side effects in dogs · antihistamines for dog allergic reaction
Abstract
Carboplatin is usually a well-tolerated drug and has many applications in veterinary oncology. The side effects of carboplatin described in the veterinary literature include myelotoxicity, nephrotoxicity, digestive and appetite disorders. In 114 dogs treated by single-agent chemotherapy with carboplatin, we observed a rate of non-haematological toxicities of 19·3% (personal observation). This case report describes the first case of cutaneous delayed-hypersensitivity to carboplatin in a dog, diagnosed according to the official ABON-system, which determines a causal association between a suspected product and a reported reaction (A=probable, B=possible, O=unclassifiable and N=unlikely), and an experimental intradermal skin test. Antihistamines were used to treat the reaction, and future carboplatin treatments were adjusted by premedication with corticosteroids, prolonged infusion and a reduction of 20% of the first dose of carboplatin. No further reactions were noted during the following treatments.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21121921/