Probiotic administration correlated with reduced diarrheal incidence and improved gut microbiota diversity in young goats.

Abstract

INTRODUCTION: Probiotic interventions in young livestock are gaining attention for their potential health benefits. METHODS: This study involved 15 weaned goat kids (2-3 months old; 10-15 kg body weight), including 10 healthy kids and 5 diarrheic kids. The kids were divided into three groups: Healthy Control (H, no treatment), Probiotic-Treated Healthy (T), and Diarrheic + Probiotic-Treated (D). All kids were maintained under standardized environmental conditions and fed a controlled diet (60% corn, 15% pea skin, 15% silage, 5% hay and 1% vitamin-mineral additives). Probiotic bacteriaandwere administered via oral gavage at a concentration of (1&#x202f;&#xd7;&#x202f;10) CFU/mL for five consecutive days. Fecal samples were collected for sequencing of the bacterial 16S rRNA gene to analyze microbial composition. RESULTS: Healthy groups exhibited significantly greater species richness and diversity compared to the diarrheal group (p < 0.01). The predominant phyla identified were,, and.Increased levels of,,, andwere noted in healthy treated kids, whileUG_001 anddecreased. DISCUSSION: The findings highlight significant gut microbiota differences between healthy and diarrheal kids, suggesting that modifications in gut microbiota composition could alleviate diarrhea, contributing to preventive and therapeutic strategies for this condition.