Peer-reviewed veterinary case report
Dog and cat with cancer causing high white blood cell count
By Sharkey, L C et al.·Published in Journal of veterinary internal medicine·1996·Department of Veterinary Biosciences, United States·View original on PubMed →
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Original publication title: Production of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor by carcinomas in a dog and a cat with paraneoplastic leukocytosis.
Plain-English summary
A dog with lung cancer and a cat with skin cancer both showed a high white blood cell count without any signs of infection or inflammation. Tests revealed that the tumors were producing substances called granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF), which can lead to this increase in white blood cells. This condition is known as paraneoplastic leukocytosis, which can occur in pets with certain types of cancer. Understanding this mechanism can help veterinarians manage the health of pets with cancer more effectively.
People also search for: dog lung cancer symptoms · cat skin cancer treatment · high white blood cell count in pets · paraneoplastic leukocytosis in dogs and cats · G-CSF in dog cancer
Abstract
A dog with a pulmonary papillary carcinoma and a cat with a dermal tubular adenocarcinoma had profound paraneoplastic neutrophilic leukocytosis with no clinically detectable inflammatory foci. To investigate the mechanism of the leukocytosis, oligonucleotide primers were designed from the cDNA sequences of granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) of dogs. Reverse transcription polymerase chain reaction was performed on tumor tissues, and specific amplification of G-CSF and GM-CSF was obtained with the tumor RNA in the dog. The tumor RNA in the cat demonstrated specific amplification of G-CSF but not GM-CSF. These findings are consistent with the production of G-CSF and/or GM-CSF by neoplasms as a mechanism for paraneoplastic leukocytosis in small animals.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/8947874/