Peer-reviewed veterinary case report
Production of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor by carcinomas in a dog and a cat with paraneoplastic leukocytosis.
- Journal:
- Journal of veterinary internal medicine
- Year:
- 1996
- Authors:
- Sharkey, L C et al.
- Affiliation:
- Department of Veterinary Biosciences · United States
Plain-English summary
A dog with lung cancer and a cat with skin cancer both showed a significant increase in white blood cells without any signs of infection or inflammation. Researchers looked into why this was happening and found that the tumors in both animals were producing substances called granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF). In the dog, both factors were present, while in the cat, only G-CSF was found. This suggests that the cancers in these pets can cause changes in blood cell production. The study indicates that the tumors are likely responsible for the increase in white blood cells in these cases.
Abstract
A dog with a pulmonary papillary carcinoma and a cat with a dermal tubular adenocarcinoma had profound paraneoplastic neutrophilic leukocytosis with no clinically detectable inflammatory foci. To investigate the mechanism of the leukocytosis, oligonucleotide primers were designed from the cDNA sequences of granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) of dogs. Reverse transcription polymerase chain reaction was performed on tumor tissues, and specific amplification of G-CSF and GM-CSF was obtained with the tumor RNA in the dog. The tumor RNA in the cat demonstrated specific amplification of G-CSF but not GM-CSF. These findings are consistent with the production of G-CSF and/or GM-CSF by neoplasms as a mechanism for paraneoplastic leukocytosis in small animals.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/8947874/