Peer-reviewed veterinary case report
Stem cell factor production in canine mast cell tumors
By Amagai, Yosuke et al.·Published in Research in veterinary science·2014·Graduate School of Bio-Applications and System Engineering, Japan·View original on PubMed →
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Original publication title: Production of stem cell factor in canine mast cell tumors.
- Species:
- dog
Plain-English summary
A dog with a mast cell tumor, the most common skin tumor in dogs, was studied to understand how a protein called stem cell factor (SCF) affects tumor growth. Researchers found that in most of the tumor samples, the levels of SCF were significantly higher, suggesting it plays a big role in the tumor's development. This means that treatments targeting the SCF pathway could be beneficial for dogs with mast cell tumors, even if they have specific genetic mutations.
People also search for: dog mast cell tumor treatment · stem cell factor in dog tumors · canine skin tumor symptoms
Abstract
Mast cell tumor (MCT) is the most common cutaneous tumor in dogs. We recently revealed that production of stem cell factor (SCF) contributes to the proliferation of neoplastic mast cells in an autocrine/paracrine manner. The aim of the present study was to determine the contribution of the mechanism in clinical MCTs. In consequence, high SCF expression (>10 times compared to HRMC cells) was observed in 5 of 7 MCT samples used in the study regardless of KIT mutation, which was confirmed in immunohistochemical analysis. In addition, production of SCF was observed in Ki-67-positive cells in the MCT xenograft. These results indicate the broad contribution of SCF autocrine/paracrine mechanism on clinical MCTs, providing the rationale for the clinical use of KIT inhibitors regardless of KIT mutation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24269079/