Peer-reviewed veterinary case report
Antibiotic resistance genes in Staphylococcus pseudintermedius
By Parasana, D K et al.·Published in Comparative immunology, microbiology and infectious diseases·2025·Department of Veterinary Microbiology, India·View original on PubMed →
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Original publication title: Profiling of antimicrobial resistance genes from Staphylococcus pseudintermedius isolated from dogs with pyoderma using whole genome sequencing.
- Species:
- dog
Plain-English summary
A group of dogs with skin infections (pyoderma) caused by a bacteria called Staphylococcus pseudintermedius was studied to understand how resistant this bacteria is to antibiotics. The research found that all the bacteria samples were resistant to several common antibiotics, but most were still sensitive to clindamycin, which could be a good treatment option. This information helps veterinarians choose the right antibiotics for treating skin infections in dogs and highlights the importance of monitoring antibiotic resistance.
People also search for: dog skin infection treatment · Staphylococcus pseudintermedius antibiotics · pyoderma in dogs · clindamycin for dog skin infections
Abstract
Staphylococcus pseudintermedius is considered as a most common cause of canine pyoderma. Antimicrobial resistance is considered as a global public health concern. The main aim of the study was to evaluate the distribution of Antimicrobial resistance genes in S. pseudintermedius isolates using whole genome sequencing. In the current work, Antimicrobial susceptibility testing and Whole genome sequencing was performed on Five S. pseudintermedius isolates recovered from canine pyoderma cases presented at Veterinary Clinical Complex, Navsari. Bioinformatics analysis of sequencing data was performed to detect Antimicrobial resistance genes, plasmids and mobile genetic elements in S. pseudintermedius isolates. All S. pseudintermedius isolates shows resistance towards amikacin, ampicillin, cefpodoxime, cephalexin, erythromycin and trimethoprim. Higher sensitivity was observed against clindamycin (4/5, 80 %). A total 15 AMR genes, one plasmid (repUS43), two insertion sequences (ISLgar5 and IS256) and one Integrative Conjugative Element (Tn6009) were detected using whole genome sequencing analysis. This study aids us to know about relationship between antimicrobial resistance and presence of AMR genes, plasmids and mobile genetic elements.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39667136/