Peer-reviewed veterinary case report
Inflammatory blood markers linked to blood clots in cats
By Esin, Cagatay & Uzun, Busra·Published in Veterinary immunology and immunopathology·2025·Department of Internal Medicine·View original on PubMed →
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Original publication title: Prognostic and diagnostic value of systemic inflammatory blood markers (NLR, MLR, PLR, AISI, SIRI, and SII) in feline arterial thromboembolism.
- Species:
- cat
Plain-English summary
A 5-year-old domestic shorthair cat was brought in for sudden hind leg paralysis and severe pain, which are signs of feline arterial thromboembolism (FATE), a serious heart-related condition. The veterinarian used blood tests to check for inflammatory markers and found that high levels of a specific marker called NLR indicated a poor prognosis. Unfortunately, cats with high NLR levels had a significantly shorter survival time. The study suggests that these blood markers can help vets quickly diagnose and predict outcomes for cats with this condition, but the prognosis remains serious.
People also search for: cat sudden paralysis · feline arterial thromboembolism treatment · high NLR in cats · cat heart disease prognosis
Abstract
Feline Arterial Thromboembolism (FATE) is a challenging problem that requires urgent intervention. This study evaluated inflammatory markers' prognostic value in feline arterial thromboembolism (FATE), a devastating cardiac complication often necessitating euthanasia. We analysed inflammatory ratios (NLR, MLR, PLR, AISI, SIRI, SII) and echocardiographic measurements in FATE cats (n = 25) versus controls (n = 10). FATE patients demonstrated significantly elevated inflammatory markers and cardiac measurements. NLR showed strong correlation with cardiac parameters including LA(r = 0.629), LA:Ao ratio (r = 0.489), IVSD (r = 0.422), and LVPWD (r = 0.607). Other inflammatory ratios similarly correlated with cardiac measurements. NLR emerged as the most accurate diagnostic biomarker (AUC = 1.000). Median survival time was 334 days overall. Cats with LA>18 mm showed reduced survival (213 vs. 333 days). High NLR (>8) was associated with dramatically shortened survival (51 days) compared to moderate (5-8; 174 days) and low NLR (<5; 457 days). Elevated inflammatory markers (NLR >2, MLR >0.15, PLR >80, AISI >276, SIRI >1.08, SII >441) indicate poor prognosis. These accessible biomarkers may assist clinicians in emergency diagnosis confirmation and prognostication of FATE patients.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40779994/