Peer-reviewed veterinary case report
Survival outlook for dogs with liver-related portal hypertension
By Calleja, Shaun et al.·Published in The Canadian veterinary journal = La revue veterinaire canadienne·2023·Murdoch University, United States·View original on PubMed →
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Original publication title: Prognostic indicators in dogs with intra-hepatic portal hypertension.
- Species:
- dog
Plain-English summary
A group of 76 dogs diagnosed with intra-hepatic portal hypertension, a serious liver condition, showed a wide range of survival times. On average, these dogs lived for about 14 days after diagnosis, with some being euthanized within just 2 days. The presence of jaundice (yellowing of the skin and eyes) was linked to a higher risk of death, while the duration of symptoms also played a role in survival. While the prognosis is generally poor, some dogs can survive for longer periods. It's important for pet owners to discuss their dog's specific situation with their veterinarian for guidance.
People also search for: dog jaundice treatment · portal hypertension in dogs · liver disease prognosis in dogs
Abstract
OBJECTIVES: The primary goals of this retrospective study were to describe a population of dogs with portal hypertension secondary to liver disease, and to assess whether prognosis could be inferred from historical, clinical, and clinicopathological data. ANIMALS AND PROCEDURES: Dogs (N = 76) diagnosed with intrahepatic portal hypertension between 2011 and 2020 were included; dogs with known congenital hepatic anomalies were excluded. Effect on survival was assessed using univariable and multivariable Cox proportional hazards models for historical, clinical, and clinicopathological variables. RESULTS: Dogs survived for a median of 14 d (range: 0 to 2028 d), with 31.6% being euthanized within 2 d of diagnosis and 23.7% surviving longer than 2 mo. Presence of jaundice and duration of clinical signs, expressed in days, were significantly associated with outcome in the univariable analysis (HR = 1.846, 95% CI: 1.094 to 3.117,= 0.02; HR = 0.995, 95% CI: 0.990 to 1.000,= 0.033, respectively). However, only presence of jaundice was significantly associated with increased hazard of death in the multivariable analysis. CONCLUSION: Results of this study show that portal hypertension is associated with a poor prognosis; however, some dogs can show prolonged survival. CLINICAL RELEVANCE: Clinical data can guide decision-making for clinicians and owners.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36733641/