Peer-reviewed veterinary case report
Blood test markers that predict survival in dogs with Babesia gibsoni
By Kandasamy, Rajamanickam et al.·Published in The Veterinary record·2021·Department of Veterinary Physiology, India·View original on PubMed →
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Original publication title: Prognostic markers and their discriminant score in predicting the outcome of Babesia gibsoni infection.
- Species:
- dog
Plain-English summary
A group of dogs with Babesia gibsoni infection, which can cause severe illness, were studied to find out how to predict which dogs might not survive. Blood tests showed that certain markers, like urea and liver enzymes, could help determine the severity of the disease. A scoring system was created that could identify dogs at high risk of dying from the infection, allowing veterinarians to provide more intensive care for those with higher scores. This could help save lives by ensuring that at-risk dogs receive prompt treatment.
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Abstract
BACKGROUND: We aimed to identify prognostic markers and their discriminant score in predicting the lethal outcome of canine Babesia gibsoni. METHODS: Blood samples were collected from 108 client-owned dogs with clinical signs commensurate with babesiosis to analyze haematological, biochemical, haemostatic, antioxidant profile and thiobarbituric acid reactive substance levels. Samples were screened for Babesia infection (microscopic and molecular techniques). Babesiosis-affected dogs were classified into survivors and non-survivors, and 30 healthy dogs were used in the control group. RESULTS: Haemoglobin, thrombocytes, catalase, urea, creatinine, alanine aminotransferase (ALT), alkaline phosphatase, lactate and reticulocytes were highly correlated to survival. Receiver operating characteristics analysis revealed urea, ALT and lactate as specific prognostic markers for the disease. The formula for calculation of discriminant scores (Di) for lethal outcome of the disease was generated with cut-off score 0.141. The scoring system was 79% sensitive and 83% specific in predicting the lethal outcome of the disease. CONCLUSIONS: A scoring system developed from the prognosticating markers may aid in predicting the outcome of Babesia gibsoni infection on the day of presentation itself enabling intensive care for those animals with a cut-off score more than 0.141.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33666974/