Peer-reviewed veterinary case report
Copper, zinc, and blood markers linked to survival in cats
By Yanar, Kerim Emre et al.·Published in Journal of veterinary internal medicine·2024·Department of Internal Medicine·View original on PubMed →
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Original publication title: Prognostic potential of copper, zinc, copper/zinc ratio, cobalamin, and serum amyloid A in cats with panleukopenia.
- Species:
- cat
Plain-English summary
A group of cats diagnosed with feline panleukopenia (a serious viral infection) had their blood tested for copper, zinc, cobalamin (a vitamin), and serum amyloid A (a protein) to see if these could help predict their chances of recovery. The results showed that cats who survived had higher levels of copper and serum amyloid A, while those who did not survive had lower levels of cobalamin. These tests could help veterinarians identify which cats are more likely to recover, with high accuracy for certain levels of these substances.
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Abstract
BACKGROUND: Copper (Cu), zinc (Zn), and the copper/zinc ratio (Cu/Zn), which have been studied in gastrointestinal disorders of humans, may facilitate disease prognosis. OBJECTIVE: Evaluate the predictive potential of Cu, Zn, cobalamin, and serum amyloid A (SAA) as prognostic indicators in cats with feline panleukopenia (FPV) on admission. ANIMALS: Client-owned cats diagnosed with FPV and controls. METHODS: Serum Cu and Zn concentrations were assessed using the spectrophotometric method and serum concentrations of SAA and cobalamin were measured by chemiluminescent immunoassay. RESULTS: On admission, survivor cats with FPV had significantly higher serum Cu and SAA concentrations and Cu/Zn ratios and significantly lower serum Zn and cobalamin concentrations than controls. Furthermore, non-survivor cats with FPV had significantly higher serum Cu and SAA concentrations and Cu/Zn ratios and significantly lower cobalamin concentrations than survivors and controls. Prognostic thresholds were calculated, with positive predictive value (PPV) for survival of 90% for Cu (≥120.3 μg/dL), 90% for Cu/Zn (≥1.34), 90% for cobalamin (≤430.4 pg/mL), and 90% for SAA (≥0.85 mg/L). CONCLUSIONS AND CLINICAL IMPORTANCE: Cu (0.93 area under curve [AUC]), Cu/Zn (0.95 AUC), cobalamin (0.98 AUC), and SAA (0.98 AUC) were excellent biomarkers for predicting prognosis in cats with FPV. Their effectiveness, as assessed by sensitivity (100%), specificity (80%), AUC (0.98), and PPV (90%) from receiver operating characteristic analysis, emphasizes the performance of cobalamin and SAA.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38613433/