Peer-reviewed veterinary case report
Genetic changes linked to prognosis in dog skin mast cell tumors
By Sirivisoot, Sirintra et al.·Published in Research in veterinary science·2026·Department of Pathology·View original on PubMed →
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Original publication title: Prognostic relevance of selected nucleotide variants in canine cutaneous mast cell tumors.
- Species:
- dog
Plain-English summary
A study looked at genetic changes in dogs with skin tumors called mast cell tumors (MCTs) to see how these changes might affect the outcome. They found that certain genetic variants, like one in the SETD2 gene, were linked to more aggressive tumors, while others were associated with less aggressive forms. Dogs with a specific variant in the TP53 gene had a higher risk of their tumors coming back sooner. The researchers suggest that these genetic markers could help predict how serious the tumors might be, but more research is needed to confirm these findings.
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Abstract
Multiple genetic variants of specific genes, such as KIT, GNAI2, and SETD2, have been reported in canine mast cell tumors (MCTs). A familiar internal tandem duplication of KIT in exon 11 is associated with poor prognosis. However, others common mutated genes in canine MCTs as increased risks to recurrence or death remain unexplored. This study investigated 39 genetic variants contributed to MCT-related risk factors and prognoses in paraffin shaved specimens from 38 low-grade and 34 high-grade MCTs using multiplex genotyping (MassARRAY, Agena Bioscience). The associations between observed genetic variants and prognostic factors were statistically analyzed. SETD2 c.1108_1109del tended to present in MCTs with aberrant expression of KIT (P = 0.05). GNB1 c.346_347delinsTA/TT wild types were likely to harbor in less aggressive MCTs (P = 0.007). MCT dogs having TP53 c.659 T > C were 1.65 times higher hazard risk on decreased time to recurrence by univariate analysis (95% CI 1.02-2.67, P = 0.041), but not in multivariate analysis. Our study suggests that SETD2 c.1108_1109del, and TP53 c.659 T > C may associate with poor prognosis; however, further study with larger samples is needed to confirm these correlations.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/41812340/