Peer-reviewed veterinary case report
Canine anal sac gland cancer survival linked to tumor features
By Pradel, J et al.·Published in Veterinary and comparative oncology·2018·Oncology Unit, United Kingdom·View original on PubMed →
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Original publication title: Prognostic significance of histopathology in canine anal sac gland adenocarcinomas: Preliminary results in a retrospective study of 39 cases.
- Species:
- dog
Plain-English summary
A 7-year-old mixed-breed dog was diagnosed with anal sac gland cancer after showing signs of discomfort and abnormal swelling in the anal area. The tumor was mostly removed through surgery, but the cancer had already spread to nearby lymph nodes. The study found that certain features of the tumor, like its growth pattern and how much it had invaded surrounding tissues, could predict how well the dog would do after treatment. Unfortunately, dogs with more aggressive tumors tended to have a poorer outcome, highlighting the importance of careful monitoring and follow-up care.
People also search for: dog anal sac cancer symptoms · anal sac gland adenocarcinoma treatment · prognosis for dog with anal sac cancer
Abstract
Metastatic rates and survival times of canine anal sac gland adenocarcinomas (ASGACs) vary among studies, making prognostication difficult. Little is known about the prognostic significance of histopathology of ASGACs. This retrospective study investigated associations between histological features, clinical presentation and outcome for 39 ASGACs. Most tumours were incompletely excised (62%) and had moderate to marked peripheral infiltration (74%). The predominant growth pattern was solid, tubules/rosettes/pseudorosettes and papillary in 49%, 46% and 5% of the cases, respectively. Nuclear pleomorphism was either moderate (77%) or mild (23%). Necrosis and lymphovascular invasion were present in 54% and 10% of the cases, respectively. All histological features except mitotic count and necrosis were associated with nodal metastasis at presentation. A statistically significant poorer outcome was identified for tumours with a solid growth pattern, moderate or marked peripheral infiltration, necrosis and lymphovascular invasion. These results need further validation in a larger cohort of dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29961964/