Peer-reviewed veterinary case report
Surgical margin and protein markers predict grade II mast cell tumor
By Ozaki, Kiyokazu et al.·Published in The Journal of veterinary medical science·2007·Department of Pathology, Japan·View original on PubMed →
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Original publication title: Prognostic significance of surgical margin, Ki-67 and cyclin D1 protein expression in grade II canine cutaneous mast cell tumor.
- Species:
- dog
Plain-English summary
A study looked at 48 dogs with grade II skin tumors called cutaneous mast cell tumors (CCMT) to see how surgical margins and certain proteins affected their chances of recovery. Dogs that had their tumors completely removed had a better chance of surviving without the cancer coming back compared to those who had incomplete removal. The study found that lower levels of a protein called ki-67 were linked to better survival rates in dogs with incomplete excisions. However, the presence of another protein, cyclin D1, was low and didn't seem to help predict outcomes. Overall, complete removal of the tumor is crucial for a better prognosis.
People also search for: dog skin tumor treatment · mast cell tumor prognosis in dogs · ki-67 protein in canine cancer
Abstract
The prognosis for canine cutaneous mast cell tumor (CCMT) is thought to be correlated with histopathological grading. However, the wide variety of histopathologic types of grade II is one of the most troublesome and difficult points for prognosis. The objective of this study is to determine the prognostic value of surgical margin, ki-67 and cyclin D1 protein expression in grade II tumor. Surgically resected specimens of solitary grade II CCMT from 48 dogs with follow-up periods over 360 days (median was 1080 days) were used in this study. The expression of cyclin D1 and ki-67 proteins was determined by morphometrically using slides stained immunocytochemically, and the correlations among the results, survival rate, and recurrence and/or metastasis rate of each dog were analyzed statistically. The recurrence and/or metastasis and mortality rate in the incomplete surgical excision group within 30 months postoperatively were higher than that of the complete surgical excision group. In the incomplete surgical excision group, dogs with low positive staining of ki-67 had a significantly better survival, but the recurrence and metastasis rate and ki-67 positivity failed to show a significant correlation. Only a small number of cases showed cyclin D1-positive tumor cells, but most of them had a poor outcome with a high recurrence rate. In grade II CCMT, incomplete excision induced a relatively high metastasis rate and poor prognosis. Ki-67 positivity is a marker for the estimation of overall survival in incomplete surgical excision cases. Cyclin D1 positivity was low and may not have a prognostic role.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18057825/