Peer-reviewed veterinary case report
Cancer markers and survival in dogs with nasal carcinoma
By Fu, Dah-Renn et al.·Published in The Journal of veterinary medical science·2014·Graduate School of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Prognostic utility of apoptosis index, Ki-67 and survivin expression in dogs with nasal carcinoma treated with orthovoltage radiation therapy.
- Species:
- dog
Plain-English summary
A group of dogs with nasal cancer were treated with radiation therapy, and researchers looked at specific cancer markers to see how they affected survival. They found that a protein called survivin was present in most of the samples, and dogs with higher levels of this protein tended to have a poorer response to treatment and shorter survival times. The study showed that while other markers didn't significantly impact survival, high survivin levels were linked to more advanced tumors and worse outcomes. This suggests that survivin could be an important factor to consider when treating dogs with nasal cancer.
People also search for: dog nasal cancer treatment · survivin protein in dogs · radiation therapy for dog cancer
Abstract
Apoptosis, Ki-67 and survivin expression have been reported as prognostic values in human cancer treated with radiation therapy. The aim of this study was to evaluate the correlation between the outcome of canine nasal carcinomas treated with radiation therapy and these cancer markers. The apoptotic index (AI) was evaluated with TUNEL assays, and an immunohistochemical evaluation was performed on Ki-67 and survivin in 33 biopsy samples taken before treatment. Median survival times were estimated using Kaplan-Meier curves and the log-rank method. The AI ranged from 0 to 0.7%, and the percentage of Ki-67-positive cells defined as the proliferative index (PI) ranged from 0.8 to 77% in all samples. Neither the AI nor the PI had a significant relationship with survival time (P=0.056 and 0.211). Survivin expression was detected in 84.9% of samples of canine nasal carcinoma. Dogs with high survivin expression were associated with poorer response to treatment and had shorter survival times (P=0.017 and 0.031). Advanced-stage tumors were also significantly associated with a high level of survivin (P=0.026). Overexpression of survivin was shown to be an unfavorable prognostic factor in dogs with nasal carcinomas treated with radiation therapy.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25452259/