Peer-reviewed veterinary case report
Pulmonary resistance by echo predicts survival in dogs with mitral
By Yuchi, Yunosuke et al.·Published in Journal of veterinary internal medicine·2023·School of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Prognostic value of pulmonary vascular resistance estimated by echocardiography in dogs with myxomatous mitral valve disease and pulmonary hypertension.
- Species:
- dog
Plain-English summary
A group of 54 dogs with myxomatous mitral valve disease (a heart condition) and signs of pulmonary hypertension (breathing difficulties) were studied to see how certain heart measurements could predict their health outcomes. The researchers found that higher pulmonary vascular resistance, measured through echocardiography, was linked to lower survival rates. This means that dogs with more severe heart issues were more likely to face serious health problems or die. The study suggests that monitoring these heart measurements can help veterinarians assess the prognosis for dogs with this condition.
People also search for: dog heart disease prognosis · myxomatous mitral valve disease in dogs · pulmonary hypertension treatment in dogs
Abstract
BACKGROUND: Progression to combined post- and pre-capillary pulmonary hypertension (PH) provides prognostic information in human patients with post-capillary PH. Pulmonary vascular resistance estimated by echocardiography (PVRecho) is useful for the stratification of dogs with myxomatous mitral valve disease (MMVD) and detectable tricuspid regurgitation. OBJECTIVES: To evaluate the prognostic value of PVRecho in dogs with MMVD. ANIMALS: Fifty-four dogs with MMVD and detectable tricuspid regurgitation. METHODS: Prospective cohort study. All dogs underwent echocardiography. The PVRecho was calculated based on tricuspid regurgitation and the velocity-time integral of the pulmonary artery flow. To evaluate the influence of echocardiographic variables on cardiac-related deaths, Cox proportional hazard analysis was performed. Additionally, Kaplan-Meier curves classified by PVRecho tertiles were made and compared using log-rank tests to evaluate the influence of PVRecho on all-cause mortality and cardiac-related death. RESULTS: The median follow-up time was 579 days. Forty-one dogs with MMVD (PH severity [number]: no or mild, 21/33; moderate, 11/11; severe, 9/10) died during the study. In the multivariable Cox proportional hazard analysis adjusted for age, sildenafil administration, and American College of Veterinary Internal Medicine stage of MMVD, left atrial to aortic diameter ratio and PVRecho remained significant (adjusted hazard ratio [95% confidence interval]: 1.2 [1.1-1.3] and 2.1 [1.6-3.0], respectively). Higher PVRecho showed a significant association with lower survival rates. CONCLUSIONS AND CLINICAL IMPORTANCE: Left atrial enlargement and high PVRecho were independent prognostic factors in dogs with MMVD and detectable tricuspid regurgitation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36994902/