Peer-reviewed veterinary case report
What blood tests predict survival in cats with panleukopenia
By Petini, Matteo et al.·Published in Journal of veterinary internal medicine·2020·San Marco Veterinary Clinic, Italy·View original on PubMed →
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Original publication title: Prognostic value of systemic inflammatory response syndrome and serum concentrations of acute phase proteins, cholesterol, and total thyroxine in cats with panleukopenia.
- Species:
- cat
Plain-English summary
A group of cats diagnosed with feline parvovirus (FPV) were evaluated to see how certain blood tests could predict their chances of survival. The study found that the level of total thyroxine (tT4) in the blood at the time of hospital admission was a strong indicator of whether the cats would survive. Specifically, a tT4 level below 0.82 µg/dL suggested a higher risk of not surviving. This information can help veterinarians assess the severity of FPV infection and guide treatment decisions.
People also search for: cat parvovirus treatment · feline parvovirus survival rate · low tT4 in cats
Abstract
BACKGROUND: Feline parvovirus (FPV) is a common and potentially lethal infectious agent in cats. OBJECTIVE: To assess the prognostic value of age, neuter status, serum concentrations of serum amyloid A (SAA), haptoglobin, cholesterol and total thyroxine (tT4), and the presence of systemic inflammatory response syndrome (SIRS) in cats with panleukopenia. ANIMALS: Client-owned cats with FPV infection diagnosed by a positive fecal ELISA test, positive PCR on feces or blood or both. METHODS: Retrospective cohort study. The electronic medical database was searched for cats with FPV infection presented between January 2010 and January 2018. Cats were divided into survivors and nonsurvivors according to their survival status 28 days after hospital admission. The prognostic importance of each variable was investigated univariately and by multivariable Cox's proportional-hazards regression. Finally, receiver operator characteristic (ROC) curve analysis was used to identify the best cutoff value for discriminating survivors from nonsurvivors for the statistically significant prognostic predictors identified by multivariable analysis. RESULTS: Seventy cats were enrolled in the study. Multivariable analysis determined that only serum tT4 concentration at hospital admission was significantly (P = .01) associated with survival. A cutoff value of 0.82 μg/dL was identified by ROC curve analysis for serum tT4 concentration in discriminating survivors from nonsurvivors. Sensitivity at this cutoff was 73.9% and specificity was 82.9% (area under the curve, 0.783; 95% confidence interval, 0.668-0.873; P < .0001). CONCLUSION AND CLINICAL RELEVANCE: Serum tT4 concentration at hospital admission has prognostic value in cats with FPV infection.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31977127/