Peer-reviewed veterinary case report
Chronic kidney disease progression in cats after ureteral bypass
By Bennett, Zoe et al.·Published in Journal of veterinary internal medicine·2025·Royal Veterinary College, United Kingdom·View original on PubMed →
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Original publication title: Progression of Chronic Kidney Disease in Cats After Subcutaneous Ureteral Bypass Placement Compared to Cats With Idiopathic Chronic Kidney Disease.
- Species:
- cat
Plain-English summary
A group of cats with chronic kidney disease (CKD) were studied to see how their condition progressed after they had a subcutaneous ureteral bypass (SUB) placed to relieve ureteral obstruction. The results showed that the rate of CKD progression in these cats was similar to those with idiopathic CKD (a type of kidney disease with no known cause). However, it was found that blockage of the bypass was linked to faster progression of CKD. This means that if your cat has had a SUB placed, it's important to monitor for any blockages or infections that could worsen their kidney health.
People also search for: cat chronic kidney disease treatment · cat ureteral obstruction symptoms · cat kidney disease progression after surgery
Abstract
BACKGROUND: Chronic kidney disease (CKD) is a common sequela of ureteral obstruction, but many cats are non-azotemic after subcutaneous ureteral bypass (SUB) placement. OBJECTIVES: Compare CKD progression rates after SUB placement with idiopathic CKD (iCKD), and explore variables associated with progression. ANIMALS: Seventy-one referred cats after SUB placement for ureteral obstruction and 89 primary care cats with iCKD. METHODS: Retrospective observational longitudinal study. Baseline (3-6 months after SUB or at CKD diagnosis for iCKD cases) clinicopathological data and CKD progression (≥ 25% increase in creatinine concentration [Cr]) rates were compared between iCKD and SUB cats. Univariable logistic regression identified variables associated with SUB cat CKD progression. RESULTS: Baseline Cr was lower in the SUB group (SUB, 2.0 mg/dL; iCKD, 2.3 mg/dL; p = 0.01). For SUB cats with a ≥ 25% increase in Cr within 1 year, 45% (9/20) had SUB obstruction. Of the remaining 11 cats, 35% had a positive urine culture. Only SUB blockage was associated with CKD progression in SUB cats (odds ratio, 33.33; confidence interval [CI], 3.80-292.60; p = 0.002). Progression of CKD within 1 year did not differ between groups (iCKD, 29.5%; SUB, 28.1%; p = 0.85), even after exclusion of obstructed cases (iCKD, 29.5%; SUB, 17.7%; p = 0.12). Median time to CKD progression was not different between groups (iCKD, 833 days; range, 21-2141; SUB, 653 days; range, 43-1662; p = 0.80). CONCLUSIONS AND CLINICAL IMPORTANCE: Progression of CKD after SUB placement occurs with similar frequency and time frame as in cats with iCKD, but should prompt assessment for SUB blockage and pyelonephritis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40947676/