Peer-reviewed veterinary case report
Proinflammatory cytokine expression in the lung of pigs with porcine circovirus type 2-associated respiratory disease.
- Journal:
- Research in veterinary science
- Year:
- 2011
- Authors:
- Chae, Joon-Seok & Choi, Kyoung-Seong
- Affiliation:
- College of Veterinary Medicine and BK21 Program for Veterinary Science · South Korea
Abstract
Porcine circovirus type 2 (PCV2) causes a significant health problem for the swine industry worldwide. In this study, we investigated the cytokine expression profiles (IFN-γ, IL-1α, IL-8, and IL-10) in the lungs of pigs with PCV2-associated respiratory disease. The mRNA expressions of IL-1α and IL-8 were significantly up-regulated in pigs with PCV2-associated respiratory disease, while IL-10 expression was not detected. These results suggest that the increased expressions of proinflammatory cytokines in the lungs may play an important role in the immunopathologic response in pigs with PCV2-associated respiratory disease.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20542307/