Peer-reviewed veterinary case report
Using the SsCBF ELISA test to track cat sporotrichosis treatment
By Baptista, Vivian S et al.·Published in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]·2021·Biomedical Institute, Brazil·View original on PubMed →
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Original publication title: Promising application of the SsCBF ELISA test to monitor the therapeutic response of feline sporotrichosis caused by Sporothrix brasiliensis from Brazilian epidemics.
- Species:
- cat
Plain-English summary
A group of 15 domestic cats in Rio de Janeiro was monitored for sporotrichosis, a fungal infection that can be transmitted to humans. The cats were tested using a new blood test called the SsCBF ELISA, which measures antibody levels to see how well the treatment was working. The results showed that the blood test could effectively predict how well the cats were responding to treatment, even among those with different symptoms. This test could help veterinarians better manage and treat sporotrichosis in cats, ultimately reducing the risk of transmission to humans.
People also search for: cat sporotrichosis treatment · cat fungal infection symptoms · how to treat sporotrichosis in cats
Abstract
Sporotrichosis zoonotic transmission by cats has obtained hyperendemic magnitude in Rio de Janeiro, Brazil. Atypical cases, relapses, and reinfections as well as reduced diagnostic sensitivity of conventional methods have been reported. Previously, the anti-SsCBF enzyme-linked immunosorbent assay (ELISA) test was shown to be useful as a diagnostic tool for human sporotrichosis. Effective diagnosis and treatment are critical to interrupt the chain of transmission of this major pathogen in Brazilian Public Health. To evaluate its applicability for feline sporotrichosis diagnosis and/or therapeutic follow-up, 15 domestic cats from Rio de Janeiro were clinically and laboratory monitored by cytopathology, culture, Sporothrix genotyping, and anti-SsCBF IgG levels. Subsequently, animals were divided into satisfactory and non-satisfactory therapeutic responders. Averages of antibody serum levels obtained for diagnosis (first consultation) compared with the levels found after follow-up (last consultation) were significantly different in both groups (p = 0.0002 and p = 0.038, respectively). We conclude that the SsCBF ELISA test can predict feline sporotrichosis therapeutic responses even for animals with distinct clinical evolutions.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32812211/