Peer-reviewed veterinary case report
IV paracetamol to prevent eye pressure after dog cataract surgery
By Bradley, Claire et al.·Published in Veterinary ophthalmology·2022·South Devon Referrals, United Kingdom·View original on PubMed →
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Original publication title: Prophylactic efficacy of intravenous paracetamol administration to reduce the incidence of post-operative ocular hypertension in dogs undergoing phacoemulsification: A pilot study.
- Species:
- dog
Plain-English summary
A group of 54 dogs undergoing eye surgery for cataracts received either a pain medication called paracetamol or a saline solution before and after the procedure. The goal was to see if paracetamol could help prevent high eye pressure after surgery, which can lead to complications. Results showed that fewer dogs in the paracetamol group experienced slightly elevated eye pressure compared to those who received saline. While paracetamol helped reduce the number of dogs with eye pressure over 20 mmHg, it did not significantly affect those with pressure over 25 mmHg. More research is needed to find the best ways to prevent high eye pressure after surgery.
People also search for: dog eye surgery recovery · paracetamol for dogs · high eye pressure in dogs after surgery
Abstract
PURPOSE: To determine whether intravenous administration of paracetamol can prevent postoperative ocular hypertension (POH) in dogs following routine phacoemulsification. METHODS: Diabetic and non-diabetic patients (total 54 dogs) undergoing unilateral or bilateral phacoemulsification were recruited to this placebo-controlled, prospective study. The control group received 1 ml/kg saline via intravenous infusion while the treatment group received 10 mg/kg paracetamol via intravenous infusion. Infusions were administered 30 min prior to surgery and repeated 12 h following initial administration. All patients received topical latanoprost at the conclusion of surgery. Intraocular pressure (IOP) was measured before premedication (baseline), and at 1 h, 3 h, 5 h and 18 h following extubation. POH was defined as an IOP above 25 mmHg (POH25). In addition, the number of patients with an IOP exceeding 20 mmHg was analyzed (POH20). RESULTS: POH20 occurred in 33 of 54 animals (61.1%), including 19 of 25 animals (76.0%) in the control group and 14 of 29 animals (55.2%) in the treatment group. POH25 occurred in 23 of 44 animals (52.3%), including 13 of 25 animals (52.0%) in the control group and 10 of 29 animals (34.5%) in the treatment group. Paracetamol administration showed a significant positive effect on reducing the incidence of POH20 (p = .048), but not POH25 (p = .221). CONCLUSIONS: When comparing groups, treatment with paracetamol showed a statistically significant reduction in the incidence of POH20, although no differences were observed in the incidence of POH25 between groups. Further studies are warranted to explore whether alternative drug regimes or routes of administration can provide enhanced efficacy in the prevention of POH25.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35512023/