Propofol modulates inner retina function in Beagles

Abstract

AbstractPurpose To further understand a common veterinary anesthetic, propofol (2,6‐ di‐isopropylphenol) and effects of infusion rates on the retinal neurons in Beagle dogs.Methods Standard full‐field blue xenon‐flash stimulation elicited responses of dark‐adapted eyes, which were recorded from dogs before and after a propofol infusion rate increase.Results Electroretinogram b‐waves increased significantly after the infusion rate increase and decreased with decline (P < 0.0001). Also, a weak significance (P = 0.041) for a‐wave peak amplitude increase was found after infusion rate increase. The initial part (first 18 ms) of the leading edge of the a‐wave remained unchanged. No significant differences in times to a‐ and b‐wave peaks were found.Conclusion Enhanced b‐wave response and decline is due to sensitivity of postreceptoral cells, possibly interplexiform and amacrine cells, to propofol concentration.