Peer-reviewed veterinary case report
How propofol affects retina function in Beagle dogs
By Kommonen, Bertel et al.·Published in Veterinary Ophthalmology·2007·View original on Crossref →
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Original publication title: Propofol modulates inner retina function in Beagles
- Species:
- dog
Plain-English summary
A group of Beagle dogs underwent tests to see how a common anesthetic called propofol affected their eye function. After increasing the infusion rate of propofol, the dogs showed a significant improvement in their retinal responses, particularly in the b-wave, which indicates how well the inner retina is working. This suggests that the retinal cells are sensitive to the amount of propofol given. The study helps veterinarians understand how to use propofol safely during procedures while monitoring eye function in dogs.
People also search for: Beagle eye function propofol · dog anesthesia effects on eyes · propofol retinal response in dogs
Abstract
AbstractPurpose To further understand a common veterinary anesthetic, propofol (2,6‐ di‐isopropylphenol) and effects of infusion rates on the retinal neurons in Beagle dogs.Methods Standard full‐field blue xenon‐flash stimulation elicited responses of dark‐adapted eyes, which were recorded from dogs before and after a propofol infusion rate increase.Results Electroretinogram b‐waves increased significantly after the infusion rate increase and decreased with decline (P < 0.0001). Also, a weak significance (P = 0.041) for a‐wave peak amplitude increase was found after infusion rate increase. The initial part (first 18 ms) of the leading edge of the a‐wave remained unchanged. No significant differences in times to a‐ and b‐wave peaks were found.Conclusion Enhanced b‐wave response and decline is due to sensitivity of postreceptoral cells, possibly interplexiform and amacrine cells, to propofol concentration.
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Search related cases →Original publication on Crossref: https://doi.org/10.1111/j.1463-5224.2007.00512.x