Peer-reviewed veterinary case report
Rotational thromboelastometry helps diagnose and predict outcomes
By Barthélemy, Anthony et al.·Published in The Veterinary record·2018·Intensive Care Unit (SIAMU), France·View original on PubMed →
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Original publication title: Prospective assessment of the diagnostic and prognostic utility of rotational thromboelastometry for canine disseminated intravascular coagulation.
- Species:
- dog
Plain-English summary
A group of 76 dogs with medical conditions that could lead to serious bleeding were evaluated for a condition called disseminated intravascular coagulation (DIC), which affects blood clotting. About half of these dogs showed signs of bleeding, and DIC was confirmed in 32 of them. The study found that dogs with a specific blood clotting profile (hypocoagulable) had a much higher chance of dying compared to those with normal or hypercoagulable profiles. This suggests that a test called thromboelastometry can help vets diagnose DIC and predict outcomes, especially in dogs showing severe bleeding issues.
People also search for: dog bleeding problems · DIC in dogs symptoms · thromboelastometry for dogs
Abstract
This study compared the haematological, haemostatic and thromboelastometric (TEM) parameters between dogs with and without suspected disseminated intravascular coagulation (DIC). Seventy-six dogs with a medical condition known to predispose to DIC were prospectively included in the study. Thirty-eight dogs (50 per cent) presented with haemorrhagic diatheses. DIC was diagnosed in 32 dogs (42 per cent). Thirty-five dogs (46 per cent) had a normal TEM profile, 25 dogs (33 per cent) had a hypercoagulable profile and 16 dogs (21 per cent) had a hypocoagulable profile. Except for the lysis parameters, all TEM parameters were significantly correlated with the presence of DIC in univariate and multivariate analyses. Mortality rates were significantly higher in dogs with DIC (50 per cent) than in dogs without DIC (27 per cent, P=0.043; OR 2.667, 95 per cent CI 1.049 to 6.701), and mortality rates were significantly higher in dogs with a hypocoagulable profile (69 per cent) than in dogs with a hypercoagulable (24 per cent, P=0.017; OR 4.800, 95 per cent CI 1.241 to 16.220) or a normal profile (31 per cent, P=0.046; OR 3.429; 95 per cent CI 1.006 to 11.470). All TEM parameters were significantly associated with mortality in univariate and multivariate analyses. Thromboelastometry appears to be a valuable tool for the diagnosis and prognosis of dogs with suspected DIC, especially those with a hypocoagulable profile that was associated with increased risk of death and increased risk of haemorrhagic diatheses.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30115669/