Peer-reviewed veterinary case report
Blood clots in dogs with inflammatory protein-losing enteropathy study
By Oishi, Nene et al.·Published in Journal of veterinary internal medicine·2025·Department of Companion Animal Clinical Sciences, Japan·View original on PubMed →
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Original publication title: Prospective Estimation of the Prevalence of Thromboembolism in Dogs With Inflammatory Protein-Losing Enteropathy.
- Species:
- dog
Plain-English summary
A group of 22 dogs diagnosed with inflammatory protein-losing enteropathy (iPLE) were examined to see how often they developed blood clots (thromboembolism). Out of these dogs, 3 were found to have blood clots in various locations, but only one showed noticeable symptoms, which included fluid buildup in the abdomen. The other two dogs with clots did not display any signs of illness. This study suggests that blood clots may be more common in dogs with iPLE than previously thought, as many cases might go unnoticed.
People also search for: dog inflammatory bowel disease symptoms · dog blood clots treatment · iPLE in dogs signs
Abstract
BACKGROUND: Inflammatory protein-losing enteropathy (iPLE) is thought to be associated with a hypercoagulable state and may predispose dogs to thromboembolism (TE). However, little information is available regarding the prevalence of TE in dogs with iPLE. OBJECTIVES: Estimate the prevalence of TE in dogs with iPLE and collect clinical and clinicopathologic data from dogs with iPLE with and without TE. ANIMALS: Twenty-two client-owned dogs with iPLE. METHODS: Prospective, descriptive study. Dogs definitively diagnosed with iPLE based on standard diagnostic criteria and histopathology were recruited between January 2019 and February 2024. At the time of gastrointestinal endoscopic examination, dogs with iPLE underwent thoracic and abdominal computed tomography angiography to detect TE. Clinical (e.g., clinical severity, use of corticosteroids) and clinicopathologic (e.g., albumin concentration, coagulation parameters) data were collected from dogs with iPLE with and without TE. RESULTS: Thromboembolism was found in 3/22 dogs (13.6%, 95% confidence interval: 2.9-34.9) with iPLE. The three dogs with iPLE and TE had thrombi in the left external iliac artery, pulmonary artery of the right caudal lobe, and main portal vein, respectively. The dogs with thrombi in the left external iliac artery or pulmonary artery did not show any clinical signs associated with TE, whereas the dog with portal vein thrombosis had transudative peritoneal effusion. CONCLUSION AND CLINICAL IMPORTANCE: We estimated the prevalence of TE in dogs with iPLE. In dogs with iPLE, TE could be underestimated because some affected dogs have subclinical TE.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40220264/