Peer-reviewed veterinary case report
Plasma lactate levels to predict survival in dogs with shock
By Blutinger, Alex Louis et al.·Published in Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)·2021·Emergency and Critical Care Department, United States·View original on PubMed →
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Original publication title: Prospective evaluation of plasma lactate parameters for prognosticating dogs with shock.
- Species:
- dog
Plain-English summary
A group of 71 dogs showing signs of shock, such as rapid heart rate and low blood pressure, were admitted to the emergency department for treatment. The study looked at their blood lactate levels, which can indicate how well the body is responding to shock. It found that dogs who survived had a shorter time with high lactate levels and better lactate clearance compared to those who did not survive. Overall, 61% of the dogs were able to go home after treatment, highlighting the importance of monitoring lactate levels in these critical cases.
People also search for: dog shock symptoms · high lactate levels in dogs · dog emergency treatment survival rate
Abstract
OBJECTIVE: To determine whether admission venous plasma lactate concentration, serially calculated lactate variables, or the Acute Patient Physiologic and Laboratory Evaluation (APPLE) score could discriminate hospital survivors from non-survivors in dogs presenting to the emergency department with clinical signs of shock. DESIGN: Prospective case series performed over a 24-month period. SETTING: Large urban private teaching hospital. ANIMALS: Seventy-one dogs admitted to the ICU with initial peripheral venous plasma lactate concentration > 2.5 mmol/L and clinical and hemodynamic parameters consistent with shock. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Heart rate, systolic blood pressure, temperature, initial venous plasma lactate, and APPLEscore were recorded at admission. Lactate concentrations were serially recorded at predefined time points and used to calculate lactate variables, including lactime (time lactate > 2.5 mmol/L), lactate clearance ([lactate- lactate]/ lactate× 100), and LAC(area under the lactate concentration versus time curve). Primary outcome was survival to discharge. Overall survival rate was 61%. Admission plasma lactate did not differ between groups (P = 0.28). Lactime was shorter in survivors vs non-survivors (P = 0.03). Lactate clearance at hours (h) 1, 4, 10, and 16 was greater in survivors vs non-survivors (P < 0.05). Final plasma lactate clearance differed between groups (P < 0.05). LACat time intervals 1 to 4 hours, 4 to 10 hours, 10 to 16 hours, and 16 to 24 hours was larger in non-survivors vs survivors (P < 0.05). Total LACdid not differ between groups (P = 0.51). Admission APPLEwas not different between survivors and non-survivors (P = 0.16). CONCLUSIONS: While neither single APPLEnor admission plasma lactate concentration could discriminate between hospital survivors and non-survivors, measures of lactate clearance can prognosticate survival in dogs with shock.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33709568/