Peer-reviewed veterinary case report
Platelet function and clot breakdown in dogs after trauma
By Birkbeck, Rachael et al.·Published in Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)·2024·The Ralph Veterinary Referral Centre, United Kingdom·View original on PubMed →
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Original publication title: Prospective evaluation of platelet function and fibrinolysis in 20 dogs with trauma.
- Species:
- dog
Plain-English summary
A group of 20 dogs with trauma were evaluated for their blood's ability to clot and break down clots after being injured. The dogs had varying degrees of injury, with some showing signs of shock. The tests showed that their platelet function and clot breakdown were similar to healthy dogs, meaning their blood was still functioning normally despite the trauma. Unfortunately, 4 of the dogs did not survive their injuries. Overall, the study suggests that trauma does not significantly affect platelet function in these dogs.
People also search for: dog trauma recovery · dog blood clotting issues · signs of shock in dogs · dog injury survival rate
Abstract
OBJECTIVES: To determine platelet function and assess fibrinolysis in dogs following trauma using multiple electrical impedance aggregometry and a modified thromboelastographic (TEG) technique. To determine if the severity of trauma, as assessed by the Animal Trauma Triage (ATT) score and clinicopathological markers of shock, is associated with a greater degree of platelet dysfunction and fibrinolysis. SETTING: University teaching hospital. ANIMALS: Twenty client-owned dogs with trauma (occurring <24 h prior to admission and blood sampling) and ATT score of >4 were prospectively recruited. A control group of 10 healthy dogs was included. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Platelet function was measured using multiple electrode platelet aggregometry (MEPA) utilizing arachidonic acid, ADP, and collagen agonists. Fibrinolysis was assessed in citrated whole blood with the addition of tissue plasminogen activator (tPA; 50 U/mL) using kaolin-activated TEG. Conventional statistical analysis was performed to compare coagulation parameters between the groups and assess linear correlations. Median (interquartile range) ATT score was 5 (5-7), and 65% (n = 13) of dogs suffered polytrauma. Mean (± SD) time from trauma to blood sampling was 9 hours (± 6). Median (interquartile range) shock index and plasma lactate concentration were 1.1 (0.7-2.0, n = 16) and 2.9 mmol/L (0.9-16.0, n = 18), respectively. Four dogs did not survive to discharge (20%). There were no differences between the trauma and control group coagulation variables. A moderate negative correlation between ATT score and area under the curve for ADP was found (P = 0.043, r = -0.496). CONCLUSIONS: Preliminary evaluation of platelet function measured by MEPA, and fibrinolysis measured by tPA-modified TEG, is not significantly different in this population of dogs with traumatic injury compared to healthy dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38055340/