Peer-reviewed veterinary case report
S100A12 and calprotectin levels in dogs with sepsis or SIRS
By Thames, Brittany E et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2019·Department of Clinical Sciences·View original on PubMed →
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Original publication title: Prospective evaluation of S100A12 and S100A8/A9 (calprotectin) in dogs with sepsis or the systemic inflammatory response syndrome.
- Species:
- dog
Plain-English summary
A group of dogs with serious infections (sepsis) or severe inflammation (systemic inflammatory response syndrome, or SIRS) were tested for specific proteins in their blood to see if these could help diagnose their condition. The study found that both groups had higher levels of these proteins when they were first admitted to the hospital compared to healthy dogs. However, the levels changed over the next few days, with dogs suffering from sepsis showing lower levels of these proteins as time went on. Unfortunately, the levels of these proteins did not predict whether the dogs would survive their illness.
People also search for: dog sepsis symptoms · dog SIRS treatment · dog blood test results explained
Abstract
Pattern recognition receptors (e.g., S100A12 or S100A8/A9) hold promise as inflammatory biomarkers. We prospectively determined and compared serum S100A12 and S100A8/A9 concentrations in dogs with sepsis (= 11) or systemic inflammatory response syndrome (SIRS;= 8) over a 3-d period with each other, healthy controls (= 50), and other clinical and clinicopathologic variables. Serum S100A12 and S100A8/A9 concentrations were significantly higher in dogs with sepsis or SIRS (all< 0.05) at the time of hospital admission (day 1) compared to healthy controls, with no differences between patient groups. However, septic dogs had significantly lower serum S100A12 concentrations on day 2 and day 3 (both< 0.05) compared to dogs with SIRS. Likewise, dogs with sepsis had significantly lower S100A8/A9 concentrations on day 2 (< 0.05). Neither serum S100A12 nor S100A8/A9 concentrations were associated with survival to discharge. Our results suggest a differential expression of the S100/calgranulins between dogs with sepsis and those with SIRS. Serum S100A12 or S100A8/A9 concentration at the time of hospital admission did not differentiate dogs with sepsis from those with SIRS, but the trend of S100/calgranulin concentrations during the following 24-48 h may be a useful surrogate marker for differentiating sepsis from SIRS.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31170888/