Peer-reviewed veterinary case report
Protection against Asiatic Taenia solium induced by a recombinant 45W-4B protein.
- Journal:
- Clinical and vaccine immunology : CVI
- Year:
- 2009
- Authors:
- Luo, Xuenong et al.
- Affiliation:
- Lanzhou Veterinary Research Institute · China
Abstract
Taenia solium is a great threat not only to human health but also to the pig-raising industry. Oncospheral stage-specific 45W proteins are good candidates for the development of anticysticercosis vaccines. In this study, a recombinant 45W-4B protein was highly produced and used for vaccination. Two animal trials resulted in a significant reduction in parasite burden induced by the definite protein against Asiatic T. solium, up to 97.0% and 98.4%, respectively. These provide informative results for the development of effective 45W-4B vaccines against cysticercosis caused by both Chinese and Mexican T. solium isolates and even by other isolates.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19091992/