Peer-reviewed veterinary case report
Protection of chronic renal failure by a polysaccharide from Cordyceps sinensis.
- Journal:
- Fitoterapia
- Year:
- 2010
- Authors:
- Wang, Ying et al.
- Affiliation:
- School of Life Science and Technology · China
Abstract
A water-soluble polysaccharide (CPS-2), isolated from the cultured Cordyceps sinensis, was obtained by hot-water extraction, anion-exchange and gel permeation chromatography. Its structural characteristics were investigated by PMP pre-column derivation, periodate oxidation, methylation analysis, FTIR and NMR spectroscopy. CPS-2 was found to be mostly of alpha-(1-->4)-D-glucose and alpha-(1-->3)-D-mannose, branched with alpha-(1-->4,6)-D-glucose every twelve residues on average. CPS-2 had a molecular weight of 4.39x10(4) Da. The protective effect of CPS-2 on the model of chronic renal failure was established by fulgerizing kidney. The changes in blood urea nitrogen and serum creatinine revealed that CPS-2 could significantly relieve renal failure caused by fulgerizing kidney.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19969045/