Protective effect of grape seed extract in experimental menopausal syndrome.

Abstract

UNLABELLED: Grape seed extract (GSE) is a natural product obtained from Vitis vinifera seeds; it has been used as adjuvant therapy in wide range of pathological conditions. AIM: In the present study, we investigated the ability of GSE to improve the mental status on ovariectomized rats. MATERIAL AND METHODS: GSE (10 mg/kg/day, 60 days long) was administrated orally on ovariectomized adult female rats; then the animals were investigated in open field. Additionally, were measured the hematological parameters, the plasma biochemistry, and the oxidative stress markers. RESULTS AND DISCUSSION: Treatment of GSE improved the loco motor activity in the open field, the number of crossings were almost twice in GSE treated rats (22.25 +/- 8.75) compared to placebo group (13.00 +/- 2.62) (p < 0.05). Lipid peroxides were reduced up to 51.57% (p < 0.05), while hematology and plasma biochemistry remained almost unchanged. CONCLUSION: GSE improve the mental status and reduced the level of oxidative stress in rats subject to experimental ovariectomy.