Peer-reviewed veterinary case report
High dose BN52021 protects cat eyes from retinal bruising
By Huang, Jin-Feng et al.·Published in BMC ophthalmology·2015·Department of Ophthalmology, China·View original on PubMed →
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Original publication title: Protective effect of high concentration of BN52021 on retinal contusion in cat eyes.
- Species:
- cat
Plain-English summary
A 6-month-old cat suffered a blunt injury to its eye, leading to potential retinal damage. Researchers tested a medication called BN52021 to see if it could help repair the retina after the injury. Cats that received a higher concentration of BN52021 showed improved retinal function and less damage compared to those that did not receive the treatment. The results suggest that BN52021 can help repair the retina and improve vision in cats with eye injuries.
People also search for: cat eye injury treatment · BN52021 for cat retinal damage · cat eye trauma recovery
Abstract
BACKGROUND: Blunt injuries/contusion on eyes might cause retina blunt trauma. This study is to evaluate the protective function of BN52021 against retinal trauma. METHODS: A total of 70 cats, 6 months old, were divided into six groups: Group A to E (n = 12) and normal control (N) group (n = 10). The right eyes in Group A to E were contused. All experiments were performed under general anesthetization. Retrobulbar injections of medication in right eyes were performed. Cats were administrated with 0.5 mL of normal saline (NS), dimethyl sulphoxide, 0.2 g/L BN52021, 1 g/L BN52021 and 5 g/L BN52021, respectively. Cats in Group N were administrated with 0.5 mL of NS. Intraocular pressure (IOP), flash electroretinogram (ERG), and retinal nerve fiber layer (RNFL) thickness were measured. Hematoxylin and eosin (HE) staining and transmission electron microscope (TEM) were detected. RESULTS: No significant difference was observed in IOP levels among groups. Comparing with cats in Group N, those in Group A to E showed significant lower amplitudes of rod a- and b-waves (P < 0.05). Amplitudes of rod a- and b-waves were increased by administration of high concentration of BN52021 (≥ 1 g/L). Moreover, high concentration of BN52021 decreased the RNFL thickness increased by contusion. Axons in RNFL in Group E arranged neatly at 7 days after modeling. CONCLUSIONS: The degenerated axons caused by contusion were repaired by BN52021. The administration of high concentration of (≥ 1 g/L) BN52021 could partially repair retinal function in contused cat eyes.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25956877/