Protective role of Pleurotus porrigens (Angel's wings) against gentamicin-induced nephrotoxicty in mice.

Abstract

OBJECTIVES: This study was conducted to quantitatively evaluate the recovery effects of methanolic fraction Angel's wings on gentamicin (GM)-induced nephrotoxicity. MATERIAL AND METHODS: Renal injury was achieved by injecting 100 mg/kg, intraperitoneally of GM in normal saline. Extract were administrated intraperitoneally at doses 200 and 400 mg/kg. Blood samples were examined for serum creatinine, serum urea, and blood urea nitrogen after the 10 consecutive days of treatment. RESULTS: Results show that GM-induced nephrotoxic animal model was successfully prepared. Methanolic fraction of Angel's wings attenuated the gentamicin-induced increase in level of serum creatinine, serum urea, and blood urea nitrogen. CONCLUSIONS: The present study shows that the extract at the doses 200 and 400 mg/kg, intraperitoneally offered significant nephroprotective action that is comparable with control group.