Peer-reviewed veterinary case report
Protein biomarkers in dog blood and urine linked to hip dysplasia
By Ahner, Carin E et al.·Published in Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2019·University of Missouri·View original on PubMed →
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Original publication title: Protein biomarkers in serum and urine for determining presence or absence of hip dysplasia in a canine model.
- Species:
- dog
Plain-English summary
A group of adult dogs, some with hip dysplasia and some without, had their urine and blood tested for specific protein markers to see if these could help identify hip problems. The study found that certain markers in urine and blood were significantly different between dogs with hip dysplasia and those with healthy hips. This means that testing these protein markers could be a simple and less invasive way for vets to diagnose hip dysplasia in dogs. The results suggest that this method could be quite accurate in distinguishing between dogs with and without hip issues.
People also search for: dog hip dysplasia symptoms · how to test for hip dysplasia in dogs · protein markers for dog hip problems
Abstract
This study compares serum and urine concentrations of relevant protein biomarkers among adult dogs with or without radiographic canine hip dysplasia (CHD). Adult (≥2 years of age), client-owned dogs (n = 74) radiographically categorized as having at least "good" hips (n = 49) or having "mild," "moderate," or "severe" hip dysplasia (n = 25) by the Orthopedic Foundation for Animals (OFA). Urine and serum samples were obtained from each dog at a single time-point and processed and analyzed for relevant protein biomarkers. Urinary concentrations of CTX-II (p < 0.001) and TIMP-1 (p = 0.002) were significantly lower in dogs with CHD compared to dogs with no CHD. ROC curve analyses were successful in establishing a panel of four biomarkers (urinary CTX-I and II, serum MMP-9, and serum PIICP) with high discriminatory capability for the presence or absence of hip dysplasia in adult dogs (AUC = 0.89). Urine and serum biomarkers can distinguish adult dogs with radiographic CHD from those with no CHD with a sensitivity of 0.95 and specificity of 0.77 using ROC analysis with AUC 0.89. Clinical Significance: This finding suggests that this simple, minimally invasive diagnostic technique has potential for discriminating dysplastic dogs from dogs with normal hips, with possible translational application to humans based on similar etiopathogenesis. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 9999:1-5, 2019.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30720210/