Peer-reviewed veterinary case report
Proteins found in joint fluid of dog with immune polyarthritis
By Tan, Wei Miao et al.·Published in Topics in companion animal medicine·2017·Department of Veterinary Clinical Studies·View original on PubMed →
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Original publication title: Proteomic Analysis of Synovial Fluid Obtained From a Dog Diagnosed With Idiopathic Immune-Mediated Polyarthritis.
- Species:
- dog
Plain-English summary
A 5-year-old mixed-breed dog was diagnosed with immune-mediated polyarthritis, a condition where the immune system attacks the joints, causing pain and swelling. The vet collected fluid from the dog's joint to analyze the proteins present, which can help understand the disease better. The analysis showed high levels of certain proteins that are involved in immune responses. This information can assist vets in diagnosing the condition and monitoring how well treatments are working.
People also search for: dog joint pain treatment · immune-mediated polyarthritis in dogs · dog synovial fluid analysis
Abstract
This case study is to report the proteins detected by proteomic analysis of synovial fluid from a dog diagnosed with idiopathic immune-mediated polyarthritis, and to compare it with healthy dogs. Synovial fluid was collected via arthrocentesis from a dog diagnosed with immune-mediated polyarthritis. Protein precipitation was performed on the synovial fluid, followed by isoelectric focusing and 2-dimensional gel electrophoresis. The spots on the 2-dimensional gels were analyzed using MALDI-TOF/MS. The results were then analyzed against the MASCOT database. The results from the proteomic analysis revealed an abundance of several types of immunoglobulins together with the presence of complement C4b-binding protein alpha chain. Actin and keratin were also among the proteins detected. Proteomic studies, facilitate a better understanding of the different levels of proteins expressed during disease activity. Potential disease biomarkers can aid in the diagnosis of disease, as well as help in monitoring treatment efficacy and providing prognosis for the patient.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28750786/