Peer-reviewed veterinary case report
Proteomics in veterinary medicine: applications and trends in disease pathogenesis and diagnostics.
- Journal:
- Veterinary pathology
- Year:
- 2014
- Authors:
- Ceciliani, F et al.
- Affiliation:
- Department of Veterinary Science and Public Health · Italy
Plain-English summary
Recent advancements in laboratory techniques have made it possible to study proteins in animals more effectively, which can help us understand diseases better and improve diagnostics in veterinary medicine. This review discusses how these protein studies, known as proteomics, can be used to explore how diseases develop in animals and how they can be diagnosed. It highlights new methods that identify proteins related to immune responses and how proteins in tissues can be analyzed for better disease detection. Overall, the article emphasizes the growing importance of proteomics in finding new ways to diagnose and understand animal health issues.
Abstract
Advancement in electrophoresis and mass spectrometry techniques along with the recent progresses in genomics, culminating in bovine and pig genome sequencing, widened the potential application of proteomics in the field of veterinary medicine. The aim of the present review is to provide an in-depth perspective about the application of proteomics to animal disease pathogenesis, as well as its utilization in veterinary diagnostics. After an overview on the various proteomic techniques that are currently applied to veterinary sciences, the article focuses on proteomic approaches to animal disease pathogenesis. Included as well are recent achievements in immunoproteomics (ie, the identifications through proteomic techniques of antigen involved in immune response) and histoproteomics (ie, the application of proteomics in tissue processed for immunohistochemistry). Finally, the article focuses on clinical proteomics (ie, the application of proteomics to the identification of new biomarkers of animal diseases).
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24045891/