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Peer-reviewed veterinary case report

Proton spot scanning radiation for treating dog tumors safely

By Mayer-Stankeová, Simona et al.·Published in Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·2009·Egg 643·View original on PubMed

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Original publication title: Proton spot scanning radiotherapy of spontaneous canine tumors.

Species:
dog

Plain-English summary

Thirty dogs with various tumors, including nasal tumors and soft tissue sarcomas, were treated with a new type of radiation therapy called proton spot scanning. This method delivered a total dose of 52.5 Gy in smaller fractions and was found to be safe, with no unexpected side effects. About 40% of the dogs had a complete response to the treatment, while 47% showed partial improvement. The average survival time for all dogs was about 385 days, with some dogs living significantly longer. Overall, this new treatment option appears to be effective for managing certain types of tumors in dogs.

People also search for: dog nasal tumor treatment · soft tissue sarcoma in dogs · proton therapy for dog cancer · dog tumor survival rates

Abstract

Thirty dogs with spontaneous tumors were irradiated with proton therapy using a novel spot scanning technique to evaluate the safety and efficacy of the system, and to study the acute and late radiation reactions. Nasal tumors, soft tissue sarcomas, and miscellaneous tumors of the head were treated with a median total dose of 52.5 Gy given in 3.5 Gy fractions. Acute effects, late effects, tumor response, and outcome were analyzed. No unexpected radiation reactions were seen, however two dogs did develop in-field osteosarcoma, and one dog developed in-field bone necrosis. Complete response to therapy was seen in 40% (12/30), partial response in 47% (14/30), and no response in 13% (4/30). Median survival for all dogs was 385 days (range of 14-4583 days). Dogs with nasal cavity tumors had a median survival of 385 days (range of 131-1851 days) and dogs with soft tissue sarcomas had a median survival time of 612 days (range of 65-4588 days). Treatment outcome was similar to historical controls. This new proton spot scanning technique proved to be safe and reliable.

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Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19507399/