Psychopharmacological and Neuroregenerative Effects of a NF-κB Inhibitor under Conditions of Modeled Ethanol-Induced Encephalopathy.

Abstract

We studied the psychopharmacological effects of a NF-κB inhibitor, a stimulator of the functions of progenitor cells of the nervous tissue, under conditions of modeled ethanol-induced encephalopathy. The pharmacological agent improved indicators of the orientation and exploratory behavior and reproducibility of the conditioned passive avoidance reflex in experimental animals. These effects developed against the background of a significant increase in the content and proliferative activity of neural stem cells in the subventricular zone of the brain and intensification of their specialization. The results indicate the prospects of developing fundamentally new agents with regenerative activity based on NF-κB blockers for the treatment of alcoholic encephalopathy.