Peer-reviewed veterinary case report
Psychotropic Activity of New Fluorinated Derivatives of Tetrahydrocarbasoles.
- Journal:
- Bulletin of experimental biology and medicine
- Year:
- 2016
- Authors:
- Nikolaeva, N S et al.
- Affiliation:
- Institute of Physiologically Active Substances
- Species:
- rodent
Abstract
Psychotropic properties of CA-7043× and CA-7050×, new fluorinated derivatives of tetrahydrocarbasoles, were examined on outbred CD1 mice and transgenic 5×FAD mice with Alzheimer disease. Both agents exerted cognitive-stimulating and anxiolytic effects in a dose of 5 mg/kg. In the new cage test, they retarded extinction of orientation and exploratory behavior. CA-7043× produced an anxiolytic effect on CD1 mice assessed in the open-field test and exerted cognitive-stimulating action in the new location test. In the same tests, CA-7050× demonstrated the cognitive-stimulating and anxiolytic effects on transgenic 5×FAD mice.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/26902352/