Peer-reviewed veterinary case report
Lung cancer with mixed cell types in a 10-year-old dog
By Sato, T et al.·Published in Journal of veterinary medicine. A, Physiology, pathology, clinical medicine·2005·College of Bioresource Sciences, Japan·View original on PubMed →
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Original publication title: Pulmonary adenosquamous carcinoma in a dog.
- Species:
- dog
Plain-English summary
A 10-year-old mixed-breed dog was diagnosed with a lung tumor after showing signs of respiratory distress. The tumor was found to contain both gland-like and squamous cells, indicating a rare type of lung cancer called pulmonary adenosquamous carcinoma. Unfortunately, the specifics of treatment and outcome were not detailed, but this type of cancer can be serious and often requires a thorough evaluation and treatment plan from a veterinarian. If your dog is experiencing breathing problems, it's important to consult your vet for a proper diagnosis and treatment options.
People also search for: dog lung cancer symptoms · mixed-breed dog breathing problems · treatment for dog lung tumor
Abstract
A mass that developed in the lung of a 10-year-old mixed-breed dog was pathologically examined. Histopathological examination showed papillary and tubular growth of glandular epithelium-like cells in some areas and growth of squamous cells arranged in nests in other areas, showing coexistence of adenocarcinoma and squamous cell carcinoma in a lung tumour. Immunohistochemical staining with anti-keratin-cytokeratin antibody was strongly positive for cytoplasms in both components. Electron microscopically, the neoplastic cells of the adenocarcinoma component had features of glandular cells, with microvilli, numerous free ribosomes, large round secretory granules and intercellular desmosomes. Non-keratinized squamous cells had tonofilaments and intercellular desmosomes. These findings led to the diagnosis of primary adenosquamous carcinoma, which demonstrates phenotypic profiles characteristic of both epidermal keratinocytes and glandular epithelium.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16300659/