Peer-reviewed veterinary case report
Dog with lung basaloid squamous cell carcinoma spreading to brain
By Morey-Matamalas, A et al.·Published in Journal of comparative pathology·2018·Institute for Research in Biomedicine, Spain·View original on PubMed →
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Original publication title: Pulmonary Basaloid Squamous Cell Carcinoma in a Dog.
- Species:
- dog
Plain-English summary
A 9-year-old neutered male crossbred dog showed signs of balance and coordination problems for four weeks before being examined after death. A thorough examination revealed a cancerous growth in the lungs, lymph nodes, left kidney, and brain. The type of cancer was identified as pulmonary basaloid squamous cell carcinoma, which had spread to other parts of the body. Unfortunately, due to the advanced stage of the disease, treatment options were limited, and the dog did not survive.
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Abstract
A 9-year-old neutered male crossbred dog with a 4-week history of progressive vestibulocerebellar signs was presented for necropsy examination. Gross examination revealed neoplastic growth in the lungs, thoracic lymph nodes, left kidney and cerebellum. Microscopically, the tumour consisted of an infiltrative, densely cellular, basaloid epithelial neoplastic growth with extensive areas of abrupt keratinization. Immunohistochemically, neoplastic cells expressed p63 and partially expressed cytokeratins 5/6. Based on these findings, the tumour was diagnosed as a primary pulmonary basaloid squamous cell carcinoma (BSSC) with metastasis to regional lymph nodes, kidney and brain. As far as the authors are aware, this is the first description of BSCC in an animal species.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29598999/