Peer-reviewed veterinary case report
Pulmonary Capillary Hemorrhage Induced by Diagnostic Ultrasound in Ventilated Rats.
- Journal:
- Ultrasound in medicine & biology
- Year:
- 2018
- Authors:
- Miller, Douglas L et al.
- Affiliation:
- Department of Radiology · United States
- Species:
- rodent
Abstract
Pulmonary capillary hemorrhage (PCH) can be induced by diagnostic ultrasound-a potential safety issue. Anesthetized rats were intubated for intermittent positive-pressure ventilation (IPPV) with 0 end-expiratory pressure, +4 cm HO end-expiratory pressure (PEEP) and -4 cm HO end-expiratory pressure (NEEP). Rats were imaged at 7.6 MHz with a Philips HDI 5000 ultrasound machine. The output was low (mechanical index [MI] = 0.22) for aiming and then was raised for 5 min in 20 different exposure groups with n = 8. Peak rarefactional pressure amplitudes were measured in water and de-rated for chest attenuation. The PCH areas were measured on the lung surface. At 2.2 MPa, PCH was 9.3 ± 6.6 mmfor IPPV, 1.6 ± 3.2 mmfor PEEP (p <0.001) and 26.8 ± 6.4 mmfor NEEP (p <0.001). Thresholds were 1.3 MPa for IPPV, 2.1 MPa for PEEP and 1.0 MPa for NEEP. The small ventilator pressures subtracted or added to trans-capillary stress generated by diagnostic ultrasound pulses, virtually eliminating PCH for PEEP but enhancing PCH for NEEP.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/29779887/