Peer-reviewed veterinary case report
Pulmonary blood clots and high blood pressure treated in a dog
By Horikawa, Rina et al.·Published in Journal of veterinary internal medicine·2024·School of Veterinary Science, Japan·View original on PubMed →
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Original publication title: Pulmonary thrombotic pulmonary hypertension managed using antithrombotic and pulmonary vasodilator treatment.
Plain-English summary
An 8-year-old Leonberger was brought in for severe breathing problems, turning blue, and trouble standing. The dog was treated with oxygen and medications to help with blood clots and high blood pressure in the lungs, but symptoms continued for several days. After adding a new medication to lower lung pressure, the dog's breathing improved significantly, and follow-up tests showed better heart function. Over time, the dog continued to do well with ongoing treatment, showing lasting improvement in its condition.
People also search for: Leonberger breathing problems · dog pulmonary hypertension treatment · dog cyanosis causes
Abstract
An 8-year-old Leonberger receiving immunosuppressive treatment with clinical signs of acute dyspnea, cyanosis, and difficulty standing was referred to our institution (Day 1). Treatment including oxygen, clopidogrel, and low-molecular-weight heparin was initiated for suspected pulmonary thrombosis. However, exertional dyspnea persisted until Day 10, and increased tricuspid regurgitation velocity, pulmonary vascular resistance, and McConnell's signs also were observed. Thus, beraprost sodium was administered PO on Day 11 to treat suspected pulmonary hypertension. On Day 13, contrast-enhanced computed tomography identified extensive contrast defects in the pulmonary arteries, and IV monteplase was administered on Days 14 and 18, with marked improvement in respiratory status and exertional dyspnea on Day 20. Right ventricular function and McConnell signs also improved, and tricuspid regurgitation velocity and pulmonary vascular resistance decreased. On Day 250, echocardiography indicated further improvement in pulmonary hypertension pathophysiology. The patient was still progressing well with antithrombotic and pulmonary vasodilator treatment 400 days later.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38662965/